All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

High-throughput in vitro drug assays have been impacted by recent advances in human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact-free all-optical systems simultaneously measuring action potentials (APs) and Ca(2+) transients (CaTrs). Parallel computational...

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Veröffentlicht in:Biophys J
Hauptverfasser: Paci, Michelangelo, Passini, Elisa, Klimas, Aleksandra, Severi, Stefano, Hyttinen, Jari, Rodriguez, Blanca, Entcheva, Emilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231889/
https://ncbi.nlm.nih.gov/pubmed/32298635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.03.018
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