Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach

BACKGROUND: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are in vitro models with the clear advantages of their human origin and suitability for human disease investigations. However, limitations include their incomplete characterization and variability reported in differen...

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Veröffentlicht in:Heart Rhythm
Hauptverfasser: Paci, Michelangelo, Passini, Elisa, Severi, Stefano, Hyttinen, Jari, Rodriguez, Blanca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668441/
https://ncbi.nlm.nih.gov/pubmed/28756098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2017.07.026
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