Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes

Loss-of-function long QT (LQT) mutations inducing LQT1 and LQT2 syndromes have been successfully translated to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) used as disease-specific models. However, their in vitro investigation mainly relies on experiments using small number...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Paci, Michelangelo, Casini, Simona, Bellin, Milena, Hyttinen, Jari, Severi, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274824/
https://ncbi.nlm.nih.gov/pubmed/30428582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19113583
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