Myasthenia gravis AChR antibodies inhibit function of rapsyn-clustered AChRs

OBJECTIVE: Direct inhibition of acetylcholine receptor (AChR) function by autoantibodies (Abs) is considered a rare pathogenic mechanism in myasthenia gravis (MG), but is usually studied on AChRs expressed in cell lines, rather than tightly clustered by the intracellular scaffolding protein, rapsyn,...

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Опубликовано в: :J Neurol Neurosurg Psychiatry
Главные авторы: Cetin, Hakan, Webster, Richard, Liu, Wei Wei, Nagaishi, Akiko, Koneczny, Inga, Zimprich, Fritz, Maxwell, Susan, Cossins, Judith, Beeson, David, Vincent, Angela
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2020
Предметы:
Neuromuscular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231439/
https://ncbi.nlm.nih.gov/pubmed/32165373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2019-322640
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