SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody

OBJECTIVE: To determine whether an SRC homology 2 domain-containing phosphotyrosine phosphatase 2 (SHP2) inhibitor would increase muscle-specific kinase (MuSK) phosphorylation and override the inhibitory effect of MuSK-antibodies (Abs). METHODS: The effect of the SHP2 inhibitor NSC-87877 on MuSK pho...

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Udgivet i:Neurol Neuroimmunol Neuroinflamm
Main Authors: Huda, Saif, Cao, Michelangelo, De Rosa, Anna, Woodhall, Mark, Rodriguez Cruz, Pedro M., Cossins, Judith, Maestri, Michelangelo, Ricciardi, Roberta, Evoli, Amelia, Beeson, David, Vincent, Angela
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935836/
https://ncbi.nlm.nih.gov/pubmed/31831571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000645
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