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SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody
OBJECTIVE: To determine whether an SRC homology 2 domain-containing phosphotyrosine phosphatase 2 (SHP2) inhibitor would increase muscle-specific kinase (MuSK) phosphorylation and override the inhibitory effect of MuSK-antibodies (Abs). METHODS: The effect of the SHP2 inhibitor NSC-87877 on MuSK pho...
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| Publicado no: | Neurol Neuroimmunol Neuroinflamm |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Lippincott Williams & Wilkins
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6935836/ https://ncbi.nlm.nih.gov/pubmed/31831571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000645 |
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