Resistance Mechanisms towards CD38−Directed Antibody Therapy in Multiple Myeloma

Antibodies targeting CD38 are rapidly changing the treatment landscape of multiple myeloma (MM). CD38−directed antibodies have several mechanisms of action. Fc−dependent immune effector mechanisms include complement-dependent cytotoxicity (CDC), antibody−dependent cell−mediated cytotoxicity (ADCC),...

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Bibliographic Details
Published in:J Clin Med
Main Authors: Franssen, Laurens E., Stege, Claudia A. M., Zweegman, Sonja, van de Donk, Niels W. C. J., Nijhof, Inger S.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7230744/
https://ncbi.nlm.nih.gov/pubmed/32331242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9041195
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