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Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine

Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Wat...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Koag, Myong-Chul, Jung, Hunmin, Lee, Seongmin
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229865/
https://ncbi.nlm.nih.gov/pubmed/32282906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa193
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