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Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Wat...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229865/ https://ncbi.nlm.nih.gov/pubmed/32282906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa193 |
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