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Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine
Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Wat...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229865/ https://ncbi.nlm.nih.gov/pubmed/32282906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa193 |
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