PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage-induced focus formation of 53BP1 and BRCA1, crit...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Alonso-de Vega, Ignacio, Paz-Cabrera, Maria Cristina, Rother, Magdalena B, Wiegant, Wouter W, Checa-Rodríguez, Cintia, Hernández-Fernaud, Juan Ramón, Huertas, Pablo, Freire, Raimundo, van Attikum, Haico, Smits, Veronique A J
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229830/
https://ncbi.nlm.nih.gov/pubmed/32232336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa196
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