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Human POT1 unfolds G-quadruplexes by conformational selection
The reaction mechanism by which the shelterin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understood. We report here kinetic, thermodynamic, hydrodynamic and computational studies that show that a conformational selection mechanism, in which...
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| Udgivet i: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229828/ https://ncbi.nlm.nih.gov/pubmed/32232414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa202 |
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