K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells

Barrier-to-autointegration factor (BAF) is a highly conserved protein in metazoans that has multiple functions during the cell cycle. We found that BAF is SUMOylated at K6, and that this modification is essential for its nuclear localization and function, including nuclear integrity maintenance and...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Lin, Qiaoyu, Yu, Bin, Wang, Xiangyang, Zhu, Shicong, Zhao, Gan, Jia, Mingkang, Huang, Fan, Xu, Nan, Ren, He, Jiang, Qing, Zhang, Chuanmao
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2020
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229763/
https://ncbi.nlm.nih.gov/pubmed/32332162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912984117
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