K6-linked SUMOylation of BAF regulates nuclear integrity and DNA replication in mammalian cells

Barrier-to-autointegration factor (BAF) is a highly conserved protein in metazoans that has multiple functions during the cell cycle. We found that BAF is SUMOylated at K6, and that this modification is essential for its nuclear localization and function, including nuclear integrity maintenance and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lin, Qiaoyu, Yu, Bin, Wang, Xiangyang, Zhu, Shicong, Zhao, Gan, Jia, Mingkang, Huang, Fan, Xu, Nan, Ren, He, Jiang, Qing, Zhang, Chuanmao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229763/
https://ncbi.nlm.nih.gov/pubmed/32332162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912984117
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