Fibroblast rejuvenation by mechanical reprogramming and redifferentiation

Over the course of the aging process, fibroblasts lose contractility, leading to reduced connective-tissue stiffness. A promising therapeutic avenue for functional rejuvenation of connective tissue is reprogrammed fibroblast replacement, although major hurdles still remain. Toward this, we recently...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Roy, Bibhas, Yuan, Luezhen, Lee, Yaelim, Bharti, Aradhana, Mitra, Aninda, Shivashankar, G. V.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229653/
https://ncbi.nlm.nih.gov/pubmed/32350144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911497117
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