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Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells

BACKGROUND: Inhaled nanoparticles can cross pulmonary air–blood barrier into circulation and cause vascular endothelial injury and progression of cardiovascular disease. However, the molecular mechanism underlying the vascular toxicity of copper oxide nanoparticles (CuONPs) remains unclear. We have...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: He, Hui, Zou, Zhen, Wang, Bin, Xu, Ge, Chen, Chengzhi, Qin, Xia, Yu, Chao, Zhang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229313/
https://ncbi.nlm.nih.gov/pubmed/32494130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S241157
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