Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells

BACKGROUND: Inhaled nanoparticles can cross pulmonary air–blood barrier into circulation and cause vascular endothelial injury and progression of cardiovascular disease. However, the molecular mechanism underlying the vascular toxicity of copper oxide nanoparticles (CuONPs) remains unclear. We have...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: He, Hui, Zou, Zhen, Wang, Bin, Xu, Ge, Chen, Chengzhi, Qin, Xia, Yu, Chao, Zhang, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2020
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229313/
https://ncbi.nlm.nih.gov/pubmed/32494130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S241157
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