Genome-wide CRISPR screen identifies semaphorin 6A and 6B as receptors for Paeniclostridium sordellii toxin TcsL

The exotoxin TcsL is a major virulence factor in Paeniclostridium (Clostridium) sordellii and responsible for the high lethality rate associated with P. sordellii infection. Here we present a genome-wide CRISPR-Cas9-mediated screen using a human lung carcinoma cell line and identify semaphorin (SEMA...

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Publicado en:Cell Host Microbe
Main Authors: Tian, Songhai, Liu, Yang, Wu, Hao, Liu, Hao, Zeng, Ji, Choi, Mei Yuk, Chen, Hong, Gerhard, Ralf, Dong, Min
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228847/
https://ncbi.nlm.nih.gov/pubmed/32302524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.03.007
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