CCR5 blockade inflames antitumor immunity in BAP1-mutant clear cell renal cell carcinoma

BACKGROUND: Patients with BRCA1-associated protein 1 (BAP1)-mutant clear cell renal cell carcinoma (ccRCC) have worse prognosis. C-C chemokine receptor 5 (CCR5) plays an important role in ccRCC development and its expression is elevated in BAP1-mutant tumors. METHODS: 533 patients with ccRCC from Th...

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Publicado en:J Immunother Cancer
Autores principales: Zhou, Quan, Qi, Yangyang, Wang, Zewei, Zeng, Han, Zhang, Hongyu, Liu, Zhaopei, Huang, Qiuren, Xiong, Ying, Wang, Jiajun, Chang, Yuan, Bai, Qi, Xia, Yu, Wang, Yiwei, Liu, Li, Xu, Le, Dai, Bo, Guo, Jianming, Zhu, Yu, Zhang, Weijuan, Xu, Jiejie
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228663/
https://ncbi.nlm.nih.gov/pubmed/32371459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000228
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