Strong Th1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy

Activated CD4 T cells are a major target of HIV infection. Results from the Step HIV vaccine trial highlighted a potential role for total activated CD4 T cells in promoting HIV acquisition. However, the influence of vaccine insert-specific CD4 T cell responses on HIV acquisition is not known. Here,...

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Publicado no:Sci Transl Med
Main Authors: Chamcha, Venkateswarlu, Reddy, Pradeep B.J., Kannanganat, Sunil, Wilkins, Courtney, Gangadhara, Sailaja, Velu, Vijayakumar, Green, Richard, Law, G. Lynn, Chang, Jean, Bowen, James R., Kozlowski, Pamela A., Lifton, Michelle, Santra, Sampa, Legere, Traci, Chea, Lynette S., Chennareddi, Lakshmi, Yu, Tianwei, Suthar, Mehul S., Silvestri, Guido, Derdeyn, Cynthia A., Gale, Michael, Villinger, Francois, Hunter, Eric, Amara, Rama Rao
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227795/
https://ncbi.nlm.nih.gov/pubmed/31748228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav1800
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