High doses of granulocyte-macrophage colony stimulating factor inhibit antibody responses in rectal secretions and diminish MVA/SIV vaccine protection in TRIM5α restrictive macaques

Here, we test in rhesus macaques the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/simian immunodeficiency macaque 239 (SIVmac239) vaccine. High doses of the MVA/GM-CS...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Immunol
Autores principales: Kannanganat, Sunil, Wyatt, Linda S, Gangadhara, Sailaja, Chamcha, Venkateswarlu, Chea, Lynette S., Kozlowski, Pamela A, LaBranche, Celia C, Chennareddi, Lakshmi, Lawson, Benton, Reddy, Pradeep B. J., Styles, Tiffany M., Vanderford, Thomas H, Montefiori, David C, Moss, Bernard, Robinson, Harriet L, Amara, Rama Rao
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101171/
https://ncbi.nlm.nih.gov/pubmed/27683750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600629
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares