High doses of granulocyte-macrophage colony stimulating factor inhibit antibody responses in rectal secretions and diminish MVA/SIV vaccine protection in TRIM5α restrictive macaques

Here, we test in rhesus macaques the effects of a 500-fold range of an admixed recombinant modified vaccinia Ankara (MVA) expressing rhesus GM-CSF (MVA/GM-CSF) on the immunogenicity and protection elicited by an MVA/simian immunodeficiency macaque 239 (SIVmac239) vaccine. High doses of the MVA/GM-CS...

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Publicado no:J Immunol
Main Authors: Kannanganat, Sunil, Wyatt, Linda S, Gangadhara, Sailaja, Chamcha, Venkateswarlu, Chea, Lynette S., Kozlowski, Pamela A, LaBranche, Celia C, Chennareddi, Lakshmi, Lawson, Benton, Reddy, Pradeep B. J., Styles, Tiffany M., Vanderford, Thomas H, Montefiori, David C, Moss, Bernard, Robinson, Harriet L, Amara, Rama Rao
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101171/
https://ncbi.nlm.nih.gov/pubmed/27683750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600629
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