Vaccine Candidate Brucella melitensis 16MΔvjbR Is Safe in a Pregnant Sheep Model and Confers Protection

As a natural host species for Brucella melitensis, pregnant sheep offer an ideal model to evaluate vaccine candidates for safety. B. melitensis strain Rev. 1 has been used almost exclusively to prevent brucellosis in small ruminants, but it causes abortions when given to pregnant animals. To evaluat...

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Veröffentlicht in:mSphere
Hauptverfasser: Hensel, Martha E., Garcia-Gonzalez, Daniel G., Chaki, Sankar P., Hartwig, Airn, Gordy, Paul W., Bowen, Richard, Ficht, Thomas A., Arenas-Gamboa, Angela M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227765/
https://ncbi.nlm.nih.gov/pubmed/32404509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00120-20
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