GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability

GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. Here, we show that GCNA mutants in mouse and C. elegan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Dokshin, Gregoriy A., Davis, Gregory M., Sawle, Ashley D., Eldridge, Matthew D., Nicholls, Peter K., Gourley, Taylin E., Romer, Katherine A., Molesworth, Luke W., Tatnell, Hannah R., Ozturk, Ahmet R., de Rooij, Dirk G., Hannon, Gregory J., Page, David C., Mello, Craig C., Carmell, Michelle A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227305/
https://ncbi.nlm.nih.gov/pubmed/31839538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.11.006
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