GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability

GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. Here, we show that GCNA mutants in mouse and C. elegan...

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Publicado no:Dev Cell
Main Authors: Dokshin, Gregoriy A., Davis, Gregory M., Sawle, Ashley D., Eldridge, Matthew D., Nicholls, Peter K., Gourley, Taylin E., Romer, Katherine A., Molesworth, Luke W., Tatnell, Hannah R., Ozturk, Ahmet R., de Rooij, Dirk G., Hannon, Gregory J., Page, David C., Mello, Craig C., Carmell, Michelle A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227305/
https://ncbi.nlm.nih.gov/pubmed/31839538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.11.006
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