Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer

Matrix metalloproteinase 3 (MMP3) plays multiple roles in extracellular proteolysis as well as intracellular transcription, prompting a new definition of moonlighting metalloproteinase (MMP), according to a definition of protein moonlighting (or gene sharing), a phenomenon by which a protein can per...

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Publié dans:Cancers (Basel)
Auteurs principaux: Okusha, Yuka, Eguchi, Takanori, Tran, Manh T., Sogawa, Chiharu, Yoshida, Kaya, Itagaki, Mami, Taha, Eman A., Ono, Kisho, Aoyama, Eriko, Okamura, Hirohiko, Kozaki, Ken-ichi, Calderwood, Stuart K., Takigawa, Masaharu, Okamoto, Kuniaki
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226423/
https://ncbi.nlm.nih.gov/pubmed/32260433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12040881
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