Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells

The ATP-binding cassette transporter G1 (ABCG1) is a cholesterol lipid efflux pump whose role in tumor growth has been largely unknown. Our transcriptomics revealed that ABCG1 was powerfully expressed in rapidly metastatic, aggregative colon cancer cells, in all the ABC transporter family members. C...

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Publicat a:Front Oncol
Autors principals: Namba, Yuri, Sogawa, Chiharu, Okusha, Yuka, Kawai, Hotaka, Itagaki, Mami, Ono, Kisho, Murakami, Jun, Aoyama, Eriko, Ohyama, Kazumi, Asaumi, Jun-ichi, Takigawa, Masaharu, Okamoto, Kuniaki, Calderwood, Stuart K., Kozaki, Ken-ichi, Eguchi, Takanori
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191470/
https://ncbi.nlm.nih.gov/pubmed/30364132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00376
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