Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells

The ATP-binding cassette transporter G1 (ABCG1) is a cholesterol lipid efflux pump whose role in tumor growth has been largely unknown. Our transcriptomics revealed that ABCG1 was powerfully expressed in rapidly metastatic, aggregative colon cancer cells, in all the ABC transporter family members. C...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Namba, Yuri, Sogawa, Chiharu, Okusha, Yuka, Kawai, Hotaka, Itagaki, Mami, Ono, Kisho, Murakami, Jun, Aoyama, Eriko, Ohyama, Kazumi, Asaumi, Jun-ichi, Takigawa, Masaharu, Okamoto, Kuniaki, Calderwood, Stuart K., Kozaki, Ken-ichi, Eguchi, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191470/
https://ncbi.nlm.nih.gov/pubmed/30364132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00376
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