Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells

Loss of heterozygosity or mutation of the family with sequence similarity 46, member C (FAM46C) gene on chromosome band 1p12 is associated with shorter overall survival of patients with multiple myeloma (MM). In this study, using human MM cell lines (KMS‐11, OCI‐My5, and ANBL‐6), we generated FAM46C...

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Vydáno v:Cancer Sci
Hlavní autoři: Kanasugi, Jo, Hanamura, Ichiro, Ota, Akinobu, Karnan, Sivasundaram, Lam, Vu Quang, Mizuno, Shohei, Wahiduzzaman, Md, Rahman, Md Lutfur, Hyodo, Toshinori, Konishi, Hiroyuki, Tsuzuki, Shinobu, Hosokawa, Yoshitaka, Takami, Akiyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226186/
https://ncbi.nlm.nih.gov/pubmed/32176823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14386
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