Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study

CD44, a surface marker for cancer stem cells, interacts with PKM2, a key regulator of aerobic glycolysis, and enhances the glycolytic phenotype of cancer cells leading to antioxidant protection and macromolecules’ synthesis. To clarify the clinical importance of this “cross-talk” as a mechanism of d...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Papadaki, Chara, Manolakou, Stavroula, Lagoudaki, Eleni, Pontikakis, Spyros, Ierodiakonou, Despo, Vogiatzoglou, Konstantinos, Messaritakis, Ippokratis, Trypaki, Maria, Giannikaki, Linda, Sfakianaki, Maria, Kalykaki, Antonia, Mavroudis, Dimitrios, Tzardi, Maria, Souglakos, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225941/
https://ncbi.nlm.nih.gov/pubmed/32326107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12041013
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