SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP

The anti-leukemia agent forodesine causes cytotoxic overload of intracellular deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphate (dNTP), protects cells against the effects of dNTP im...

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Pubblicato in:Cell Rep
Autori principali: Davenne, Tamara, Klintman, Jenny, Sharma, Sushma, Rigby, Rachel E., Blest, Henry T.W., Cursi, Chiara, Bridgeman, Anne, Dadonaite, Bernadeta, De Keersmaecker, Kim, Hillmen, Peter, Chabes, Andrei, Schuh, Anna, Rehwinkel, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225753/
https://ncbi.nlm.nih.gov/pubmed/32402273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107640
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