Decreased Vacuolar Ca(2+) Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca(2+) Dysregulation in S. cerevisiae

The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeast does not endogenously express α-synuclein. In this...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Callewaert, Geert, D’hooge, Petra, Ma, Tien-Yang, Del Vecchio, Mara, Van Eyck, Vincent, Franssens, Vanessa, Winderickx, Joris
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225347/
https://ncbi.nlm.nih.gov/pubmed/32457789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00266
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