The Ca(2+)/Mn(2+) ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, which arises from a yet elusive concurrence between genetic and environmental factors. The protein α-synuclein (αSyn), the principle toxic effector in PD, has been shown to interfere with neuronal Ca(2+)...

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Bibliographische Detailangaben
Hauptverfasser: Büttner, S, Faes, L, Reichelt, W N, Broeskamp, F, Habernig, L, Benke, S, Kourtis, N, Ruli, D, Carmona-Gutierrez, D, Eisenberg, T, D'hooge, P, Ghillebert, R, Franssens, V, Harger, A, Pieber, T R, Freudenberger, P, Kroemer, G, Sigrist, S J, Winderickx, J, Callewaert, G, Tavernarakis, N, Madeo, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569987/
https://ncbi.nlm.nih.gov/pubmed/23154387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.142
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