Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2′-Deoxycytidine Against Pancreatic Cancer

Aberrant DNA methylation, especially hypermethylation of tumor suppressor genes, has been associated with many cancers' progression. 5-Aza-2′-deoxycytidine (DAC) can reverse hypermethylation-induced gene silencing via regulating DNA methyltransferases (DNMTs) activity, In addition, low-dose of...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Kong, Rui, Sun, Guangming, Li, Xina, Wu, Linfeng, Li, Le, Li, Yilong, Wang, Fei, Xuan, Ping, Yang, Shifeng, Sun, Bei, Hu, Jisheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225308/
https://ncbi.nlm.nih.gov/pubmed/32457835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00612
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