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Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure

Genome editing by Clustered Regularly Inter Spaced Palindromic Repeat (CRISPR) associated (Cas) systems has revolutionized medical research and holds enormous promise for correcting genetic diseases. Understanding how these Cas nucleases work and induce mutations, as well as identifying factors that...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Chechik, Lyuba, Martin, Ophelie, Soutoglou, Evi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225291/
https://ncbi.nlm.nih.gov/pubmed/32457906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00319
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