Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

Complex traits are known to be influenced by a combination of environmental factors and rare and common genetic variants. However, detection of such multivariate associations can be compromised by low statistical power and confounding by population structure. Linear mixed effects models (LMM) can ac...

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Vydáno v:PLoS Genet
Hlavní autoři: Bhatnagar, Sahir R., Yang, Yi, Lu, Tianyuan, Schurr, Erwin, Loredo-Osti, JC, Forest, Marie, Oualkacha, Karim, Greenwood, Celia M. T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224575/
https://ncbi.nlm.nih.gov/pubmed/32365090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008766
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