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Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

Complex traits are known to be influenced by a combination of environmental factors and rare and common genetic variants. However, detection of such multivariate associations can be compromised by low statistical power and confounding by population structure. Linear mixed effects models (LMM) can ac...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Genet
Main Authors: Bhatnagar, Sahir R., Yang, Yi, Lu, Tianyuan, Schurr, Erwin, Loredo-Osti, JC, Forest, Marie, Oualkacha, Karim, Greenwood, Celia M. T.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224575/
https://ncbi.nlm.nih.gov/pubmed/32365090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008766
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