Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei

FSHD is characterized by the misexpression of DUX4 in skeletal muscle. Although DUX4 upregulation is thought to be the pathogenic cause of FSHD, DUX4 is lowly expressed in patient samples, and analysis of the consequences of DUX4 expression has largely relied on artificial overexpression. To better...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Jiang, Shan, Williams, Katherine, Kong, Xiangduo, Zeng, Weihua, Nguyen, Nam Viet, Ma, Xinyi, Tawil, Rabi, Yokomori, Kyoko, Mortazavi, Ali
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224571/
https://ncbi.nlm.nih.gov/pubmed/32365093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008754
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