Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

Viral escape from CD8(+) cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that CD8(+) T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune escape variant Y4F is restored...

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Vydáno v:PLoS Pathog
Hlavní autoři: Duru, Adil Doganay, Sun, Renhua, Allerbring, Eva B., Chadderton, Jesseka, Kadri, Nadir, Han, Xiao, Peqini, Kaliroi, Uchtenhagen, Hannes, Madhurantakam, Chaithanya, Pellegrino, Sara, Sandalova, Tatyana, Nygren, Per-Åke, Turner, Stephen J., Achour, Adnane
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224568/
https://ncbi.nlm.nih.gov/pubmed/32365082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008244
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