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Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin
MHC-I epitope presentation to CD8(+) T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases underlying peptide selection and binding by MHC-I remain largely unknown. Within the peptide-loading complex, the peptide editor tapasin i...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2019
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6421438/ https://ncbi.nlm.nih.gov/pubmed/30808808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807656116 |
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