Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin

MHC-I epitope presentation to CD8(+) T cells is directly dependent on peptide loading and selection during antigen processing. However, the exact molecular bases underlying peptide selection and binding by MHC-I remain largely unknown. Within the peptide-loading complex, the peptide editor tapasin i...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Hafstrand, Ida, Sayitoglu, Ece Canan, Apavaloaei, Anca, Josey, Benjamin John, Sun, Renhua, Han, Xiao, Pellegrino, Sara, Ozkazanc, Didem, Potens, Renée, Janssen, Linda, Nilvebrant, Johan, Nygren, Per-Åke, Sandalova, Tatyana, Springer, Sebastian, Georgoudaki, Anna-Maria, Duru, Adil Doganay, Achour, Adnane
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421438/
https://ncbi.nlm.nih.gov/pubmed/30808808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807656116
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