Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer. However, efficient identification of clinical candidate TCRs is complicated by the size and complexity of T cell repertoires and the challenges of working with primary T cells...

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Publicado en:Nat Biotechnol
Main Authors: Spindler, Matthew J., Nelson, Ayla L., Wagner, Ellen K., Oppermans, Natasha, Bridgeman, John S., Heather, James M., Adler, Adam S., Asensio, Michael A., Edgar, Robert C., Lim, Yoong Wearn, Meyer, Everett H., Hawkins, Robert E., Cobbold, Mark, Johnson, David S.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224336/
https://ncbi.nlm.nih.gov/pubmed/32393905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0438-y
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