Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer. However, efficient identification of clinical candidate TCRs is complicated by the size and complexity of T cell repertoires and the challenges of working with primary T cells...

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Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Spindler, Matthew J., Nelson, Ayla L., Wagner, Ellen K., Oppermans, Natasha, Bridgeman, John S., Heather, James M., Adler, Adam S., Asensio, Michael A., Edgar, Robert C., Lim, Yoong Wearn, Meyer, Everett H., Hawkins, Robert E., Cobbold, Mark, Johnson, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224336/
https://ncbi.nlm.nih.gov/pubmed/32393905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0438-y
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