Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury

Hypoxic injury results in cell death, tissue damage and activation of inflammatory pathways. This is mediated by pathological Connexin43 (Cx43) hemichannel (HC) opening resulting in osmotic and ionic imbalances as well as cytokine production perpetuating the inflammatory environment. Gap19 is an int...

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Bibliografiske detaljer
Udgivet i:Drug Deliv Transl Res
Main Authors: Coutinho, Frazer P., Green, Colin R., Acosta, Monica L., Rupenthal, Ilva D.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223318/
https://ncbi.nlm.nih.gov/pubmed/32318976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-020-00763-y
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