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Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury

Hypoxic injury results in cell death, tissue damage and activation of inflammatory pathways. This is mediated by pathological Connexin43 (Cx43) hemichannel (HC) opening resulting in osmotic and ionic imbalances as well as cytokine production perpetuating the inflammatory environment. Gap19 is an int...

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Foilsithe in:Drug Deliv Transl Res
Main Authors: Coutinho, Frazer P., Green, Colin R., Acosta, Monica L., Rupenthal, Ilva D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer US 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223318/
https://ncbi.nlm.nih.gov/pubmed/32318976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13346-020-00763-y
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