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Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain
BACKGROUND: The most currently used general anaesthetics are potent potentiators of γ-aminobutyric acid A (GABA(A)) receptors and are invariably neurotoxic during the early stages of brain development in preclinical animal models. As causality between GABA(A) potentiation and anaesthetic-induced dev...
Gespeichert in:
| Veröffentlicht in: | Br J Anaesth |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7222221/ https://ncbi.nlm.nih.gov/pubmed/32151384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2020.01.013 |
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