Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain

BACKGROUND: The most currently used general anaesthetics are potent potentiators of γ-aminobutyric acid A (GABA(A)) receptors and are invariably neurotoxic during the early stages of brain development in preclinical animal models. As causality between GABA(A) potentiation and anaesthetic-induced dev...

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Bibliographic Details
Published in:Br J Anaesth
Main Authors: Tesic, Vesna, Joksimovic, Srdjan M., Quillinan, Nidia, Krishnan, Kathiresan, Covey, Douglas F., Todorovic, Slobodan M., Jevtovic-Todorovic, Vesna
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Neuroscience and Neuroanaesthesia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222221/
https://ncbi.nlm.nih.gov/pubmed/32151384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2020.01.013
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