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Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?

Neuroactive steroids with potentiating effects on GABA(A) channels and inhibitory effects on T-type Ca(2+) channels which are located in peripheral sensory neurons are potent modulators of pain perception. The focus of this review is on peripheral anti-nociceptive properties of 5α- and 5β-reduced ne...

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Detalles Bibliográficos
Main Authors: Jevtovic-Todorovic, Vesna, Covey, Douglas F., Todorovic, Slobodan M.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795041/
https://ncbi.nlm.nih.gov/pubmed/19577375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2009.06.001
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