Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain

BACKGROUND AND PURPOSE: Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type calcium channels. Here, we examine its potential analgesic effects and adjuvant anaesthetic properties using a post‐surgical pain model in r...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Joksimovic, Sonja Lj., Joksimovic, Srdjan M., Manzella, Francesca M., Asnake, Betelehem, Orestes, Peihan, Raol, Yogendra H., Krishnan, Kathiresan, Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070174/
https://ncbi.nlm.nih.gov/pubmed/31732978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14930
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