Understanding the Hsp90 N-Terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922)

Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a molecular chaperone that facilitates protein maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 is highly dependent on adenosine triphosphate (ATP) binding to the N-termin...

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Veröffentlicht in:Molecules
Hauptverfasser: Magwenyane, Ayanda M., Mhlongo, Ndumiso N., Lawal, Monsurat M., Amoako, Daniel G., Somboro, Anou M., Sosibo, Sphelele C., Shunmugam, Letitia, Khan, Rene B., Kumalo, Hezekiel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221724/
https://ncbi.nlm.nih.gov/pubmed/32295059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25081785
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