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1,4,7-Triazacyclononane Restores the Activity of β-Lactam Antibiotics against Metallo-β-Lactamase-Producing Enterobacteriaceae: Exploration of Potential Metallo-β-Lactamase Inhibitors

Metallo-β-lactamase (MBL)-producing Enterobacteriaceae are of grave clinical concern, particularly as there are no metallo-β-lactamase inhibitors approved for clinical use. The discovery and development of MBL inhibitors to restore the efficacy of available β-lactams are thus imperative. We investig...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Somboro, Anou M., Amoako, Daniel G., Osei Sekyere, John, Kumalo, Hezekiel M., Khan, René, Bester, Linda A., Essack, Sabiha Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344617/
https://ncbi.nlm.nih.gov/pubmed/30478231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02077-18
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