Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation

Advances in microbiome research suggest involvement in chronic inflammatory diseases such as rheumatoid arthritis (RA). Searching for initial trigger(s) in RA, we compared transcriptome profiles of highly inflamed RA synovial tissue (RA-ST) and osteoarthritis (OA)-ST with 182 selected reference tran...

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Pubblicato in:Sci Rep
Autori principali: Smiljanovic, Biljana, Grützkau, Andreas, Sörensen, Till, Grün, Joachim R., Vogl, Thomas, Bonin, Marc, Schendel, Pascal, Stuhlmüller, Bruno, Claussnitzer, Anne, Hermann, Sandra, Ohrndorf, Sarah, Aupperle, Karlfried, Backhaus, Marina, Radbruch, Andreas, Burmester, Gerd R., Häupl, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220941/
https://ncbi.nlm.nih.gov/pubmed/32404914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64431-4
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