Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation

Advances in microbiome research suggest involvement in chronic inflammatory diseases such as rheumatoid arthritis (RA). Searching for initial trigger(s) in RA, we compared transcriptome profiles of highly inflamed RA synovial tissue (RA-ST) and osteoarthritis (OA)-ST with 182 selected reference tran...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Smiljanovic, Biljana, Grützkau, Andreas, Sörensen, Till, Grün, Joachim R., Vogl, Thomas, Bonin, Marc, Schendel, Pascal, Stuhlmüller, Bruno, Claussnitzer, Anne, Hermann, Sandra, Ohrndorf, Sarah, Aupperle, Karlfried, Backhaus, Marina, Radbruch, Andreas, Burmester, Gerd R., Häupl, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220941/
https://ncbi.nlm.nih.gov/pubmed/32404914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64431-4
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