The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between skin disease and systemic exacerbations in SLE remains elusive. In an acute model of UVB-trigg...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Skopelja-Gardner, Sladjana, An, Jie, Tai, Joyce, Tanaka, Lena, Sun, Xizhang, Hermanson, Payton, Baum, Rebecca, Kawasumi, Masaoki, Green, Richard, Gale Jr., Michael, Kalus, Andrea, Werth, Victoria P., Elkon, Keith B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220927/
https://ncbi.nlm.nih.gov/pubmed/32404939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64865-w
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